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Neuron-Specific Enolase & Myelin Basic Protein:Relation of CSF Concentr to Neuro Cond of Asphyx Full-Term Infants Pediatrics 93:234-240, Garcia-Alix,A.,et al, 1994 See this aricle in Pubmed Article Abstract Twenty infants had no neonatal encephalopathy and 49 exhibited different stages of encephalopathy.NSE and MBP concentrations in CSF at 12 and 72 hours of life were related to the degree of neonatal encephalopathy. Neither NSE nor MBP levels were correlated with any perinatal factors. Infants with documented brain injury had the highest concentrations of both NSE and MBP.The concentrations of these two biochemical markers at both 12 and 72 hours correlated with adverse outcome(death or cerebral palsy at 1 year).Based on a receiver operating characteristics curve analysis for any given specificity,NSE at 12 hours was a more accurate marker than MBP at either5 12 or 72 hours for distinguishing infants with motor impairment at age 1 year from infants with normal outcome at the same age.Our findings suggest that NSE and MBP are reliable biochemical markers for early estimates of hypoxic-ischemic brain damage in asphyctic full-term newborns,NSE being superior to MBP.

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,abnormal cerebrospinal fluid,enzymes in developmental disability enolase hypoxia hypoxia,newborn hypoxic encephalopathy myelin basic protein neuron specific enolase prognosis

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